Restarting Anticoagulation After Hemorrhage With or Without Reversal

We have accepted that while NOACs (non-vitamin K-dependent oral anticoagulants) are associated with fewer major bleeding complications than warfarin, the fact remains that one cannot treat a patient with an anticoagulant (or, for that matter, an anti-platelet agent—and certainly both!) without increasing that patient’s bleeding risk from baseline. Hopefully, the...

REVERSAL, REPLETION, AND RATIONAL USE

Because of the aging of the population and the continued success in prolonging the lifespans of patients with cardiovascular disorders such as atrial fibrillation and severe valvular disease, more and more patients—particularly among elderly cohorts—are on chronic oral anticoagulation therapy. Because of the aging of the population and the well-recognized...

VKA vs NOAC

The title represents the ultimate alphabet soup, no? Most practicing physicians, however, would recognize these acronyms and have probably committed to one or the other as a preferred agent in their own patient management decisions. VKAs and NOACs are anticoagulants—that is, they prevent blood from clotting properly, which is a...